Four-Body Scoring Function for Mutagenesis

Four-Body Scoring Function for Mutagenesis

MOTIVATION There is a need for an efficient and accurate computational method to identify the effects of single- and multiple-residue mutations on the stability and reactivity of proteins. Such a method should ideally be consistent and yet applicable in a widespread manner, i.e. it should be applied to various proteins under the same parameter settings, and have good predictive power for all of...

Body condition scoring of sheep

Neural Scoring Function for MST Parser

Continuous word representations appeared to be a useful feature in many natural language processing tasks. Using fixed-dimension pre-trained word embeddings allows avoiding sparse bag-of-words representation and to train models with fewer parameters. In this paper, we use fixed pre-trained word embeddings as additional features for a neural scoring function in the MST parser. With the multi-lay...

Effective scoring function for protein sequence design.

We have developed an effective scoring function for protein design. The atomic solvation parameters, together with the weights of energy terms, were optimized so that residues corresponding to the native sequence were predicted with low energy in the training set of 28 protein structures. The solvation energy of non-hydrogen-bonded hydrophilic atoms was considered separately and expressed in a ...

Integral equations for the four-body problem